ANTIINFLAMATION TEST OF COMBINATION EXTRACT OF Sea cucumber (HOLOTHURIA SCABRA) AND KERSEN LEAF (MUNTINGIA CALABURA L.) ON RAT (RATTUS NORVEGICUS)

  • Asril Burhan akademi Farmasi Kebangsaan Makassar
  • Marwati Marwati Sekolah Tinggi Ilmu Farmasi Makassar
  • Besse Hardianti Sekolah Tinggi Ilmu Farmasi Makassar
  • Waode Ratnasari Hasan Sekolah Tinggi Ilmu Farmasi Makassar

Abstract

Sea cucumber (Holothuria scabra) and Kersen leaf (Muntingia calabura L.) are used as traditional medicines that have anti-inflammatory activity. This study aims to determine the anti-inflammatory activity of a combination of ethanol extract of sea cucumber sand and Kersen leaves on the decrease of edema in the feet of rats that have been induced with 1% carrageenan. The rats were then divided into 5 groups and each group consisted of 3 rats. Group 1 as positive control, group 2 as negative control, group 3 as extract combination 1: 1 (200 mg / kg body weight: 200 mg / kg body weight), group 4 as extract combination 1: 2 (200 mg / kg body weight: 400 mg / kg body weight) ), group 5 as extract combination 2: 1 (400 mg / kgBB: 200 mg / kgBB), and each group is given orally. At 2: 1 EK has the same anti-inflammatory effect as positive control with% DAI, which is 4.84%. Whereas at EK 1: 2 with% DAI 4.24% and EK 1: 1 with% DAI 1.81%.
Published
2019-06-19
How to Cite
BURHAN, Asril et al. ANTIINFLAMATION TEST OF COMBINATION EXTRACT OF Sea cucumber (HOLOTHURIA SCABRA) AND KERSEN LEAF (MUNTINGIA CALABURA L.) ON RAT (RATTUS NORVEGICUS). Jurnal Ilmiah Manuntung, [S.l.], v. 5, n. 1, p. 26-29, june 2019. ISSN 2477-1821. Available at: <http://jurnal.akfarsam.ac.id/index.php/jim_akfarsam/article/view/204>. Date accessed: 08 dec. 2019.